{"id":104,"date":"2020-04-18T05:23:02","date_gmt":"2020-04-18T05:23:02","guid":{"rendered":"https:\/\/jupiterx.artbees.net\/nutrition-coach\/?p=104"},"modified":"2021-06-11T06:58:19","modified_gmt":"2021-06-11T06:58:19","slug":"du%cc%88s%cc%a7u%cc%88k-yumurtalik-over-rezervi%cc%87","status":"publish","type":"post","link":"https:\/\/drozkanozdamar.com\/?p=104","title":{"rendered":"D\u00fc\u015f\u00fck Yumurtal\u0131k Rezervi"},"content":{"rendered":"\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t
\n\t\t\t\t\t

D\u00dc\u015e\u00dcK YUMURTALIK (OVER) REZERV\u0130<\/strong><\/p>

\u00a0<\/p>

Over Rezervi Ne Anlama Gelir?<\/strong><\/p>

\u2018Yumurtal\u0131k Rezervi\u2019 terimi, oosit olarak da bilinen yumurtalar\u0131n\u0131z\u0131n say\u0131s\u0131 ve kalitesi anlam\u0131na gelir. Yumurtal\u0131k rezerviniz azalm\u0131\u015fsa bu durum, yumurtalar\u0131n\u0131z\u0131n say\u0131s\u0131n\u0131n ve kalitesinin ya\u015f\u0131n\u0131za g\u00f6re beklenenden daha d\u00fc\u015f\u00fck oldu\u011fu anlam\u0131na gelir. D\u00fc\u015f\u00fck yumurtal\u0131k rezervi (DOR), her ya\u015ftan insan\u0131 etkileyebilir. Amerika Birle\u015fik Devletleri\u2019nde yap\u0131lm\u0131\u015f bir ara\u015ft\u0131rmaya g\u00f6re, rahmi olan ki\u015filerin yakla\u015f\u0131k y\u00fczde 10’u bu sorun ile kar\u015f\u0131 kar\u015f\u0131yad\u0131r. Azalm\u0131\u015f yumurtal\u0131k rezervinin maalesef tedavisi bulunmamaktad\u0131r, ancak bu duruma ra\u011fmen hamile kalmak m\u00fcmk\u00fcnd\u00fcr.<\/p>

D\u00fc\u015f\u00fck yumurtal\u0131k rezervi (DOR), yumurtal\u0131\u011f\u0131n normal \u00fcreme potansiyelini kaybetti\u011fi ve do\u011furganl\u0131\u011f\u0131n tehlikeye girdi\u011fi bir durumdur. Bu durum, hastal\u0131k veya yaralanmadan kaynaklanabilir, ancak \u00e7o\u011funlukla normal ya\u015flanman\u0131n bir sonucu olarak ortaya \u00e7\u0131kar. DOR, infertilite nedeni ile doktora ba\u015fvuran hastalar\u0131n % 10-30’unda mevcuttur.<\/p>

\u00a0<\/p>

Ya\u015fa g\u00f6re ortalama yumurta say\u0131s\u0131 nedir? <\/strong><\/p>

Yumurtal\u0131k rezervinizdeki \u201cortalama\u201d yumurta say\u0131s\u0131 ya\u015fa ba\u011fl\u0131d\u0131r. Hen\u00fcz siz annenizin rahmindeyken kendi yumurtalar\u0131n\u0131z olu\u015fmu\u015ftur. Ba\u015fka bir deyi\u015fle, sahip olaca\u011f\u0131n\u0131z t\u00fcm yumurtalarla beraber d\u00fcnyaya gelirsiniz. Bu seviyeden itibaren, yumurta rezerviniz zamanla azal\u0131r. Yumurtal\u0131k rezervinizi bir sepet yumurta olarak d\u00fc\u015f\u00fcnebilirsiniz. Tipik olarak bir sepet dolusu yumurta ile do\u011fars\u0131n\u0131z ve bu yumurtalar hayat\u0131n\u0131z boyunca t\u00fckenir. American College of Obstetricians and Gynecologists’e g\u00f6re, bunlar her ya\u015fta sahip oldu\u011funuz ortalama yumurta say\u0131s\u0131d\u0131r:<\/p>

  • 20 haftal\u0131k gebelik: 6 ila 7 milyon oosit<\/li>
  • Do\u011fum: 1 ila 2 milyon oosit<\/li>
  • Ergenlik: 300.000 ila 500.000 oosit<\/li>
  • 37 ya\u015f civar\u0131nda: kabaca 25.000 oosit<\/li>
  • 51 ya\u015f civar\u0131nda, (ABD\u2019deki ortalama menopoz ya\u015f\u0131): kabaca 1.000 oosit<\/li><\/ul>

    Yumurtal\u0131k rezervi azalm\u0131\u015f olanlar, olmayanlara g\u00f6re daha az yumurtaya sahipken, bu durumdaki kad\u0131nlar i\u00e7in ortalama yumurta say\u0131s\u0131 konusunda net bir fikir birli\u011fi yoktur. 2015 tarihli bir makalede belirtildi\u011fi gibi, azalan yumurtal\u0131k rezervi genellikle yumurtal\u0131k rezervindeki yumurta say\u0131s\u0131yla de\u011fil hormon seviyeleri ile tan\u0131mlan\u0131r, bu da durumun tan\u0131m\u0131n\u0131 kafa kar\u0131\u015ft\u0131r\u0131c\u0131 hale getirir. Azalm\u0131\u015f yumurtal\u0131k rezervi, yumurtalar\u0131 saymakla de\u011fil, hormon seviyelerini \u00f6l\u00e7en kan testleri ile te\u015fhis edildi\u011finden, azalm\u0131\u015f yumurtal\u0131k rezervi olan birinin ortalama yumurta say\u0131s\u0131n\u0131 belirlemek zordur.<\/p>

    \u00a0<\/p>

    DOR’a Ne Sebep Olur?<\/strong><\/p>

    Kad\u0131nlar ya\u015fland\u0131k\u00e7a do\u011fal do\u011furganl\u0131k potansiyelleri azalmaya ba\u015flar. Bu durum evrenseldir ve 30 ya\u015f gibi erken bir ya\u015fta g\u00f6r\u00fclebilir ve bunu izleyen on y\u0131lda daha belirgin hale gelir. Tipik olarak, az say\u0131da kad\u0131n 40’l\u0131 ya\u015flar\u0131n\u0131n ortas\u0131na kadar normal do\u011furganl\u0131\u011f\u0131 korur. Yard\u0131mla \u00fcreme, do\u011furganl\u0131ktaki bu azalmadan sorumlu yumurtalardaki de\u011fi\u015fiklikleri tersine \u00e7evirmedi\u011finden, IVF uygulanan hastalar\u0131n ba\u015far\u0131 oranlar\u0131, pop\u00fclasyonun b\u00fcy\u00fck b\u00f6l\u00fcm\u00fcnde g\u00f6r\u00fclen do\u011fal do\u011furganl\u0131ktaki normal d\u00fc\u015f\u00fc\u015fe paraleldir. Hastal\u0131k veya genetik anormallikler bu d\u00fc\u015f\u00fc\u015f\u00fc h\u0131zland\u0131rabilir.<\/p>

    N\u00fcfusun y\u00fczde biri, 40 ya\u015f\u0131ndan \u00f6nce yumurtal\u0131k yetmezli\u011fi (erken menopoz) ya\u015far. Bu durum, erken yumurtal\u0131k yetmezli\u011fi veya erken menopoz olarak adland\u0131r\u0131l\u0131r. DOR hastalar\u0131, erken yumurtal\u0131k yetmezli\u011fine yol a\u00e7an kal\u0131tsal bir durum olan ve ayn\u0131 zamanda kal\u0131tsal zihinsel engellili\u011fin ve otizmin en yayg\u0131n nedeninden de sorumlu olan Frajil X Sendromu<\/em> i\u00e7in bir kan testi ile taranmal\u0131d\u0131r (FMR1<\/em> geni premutasyonu).<\/p>

    \u00a0<\/p>

    DOR’un belirtileri nelerdir?<\/strong><\/p>

    Ne yaz\u0131k ki \u00e7o\u011fu kad\u0131n DOR belirtisi veya semptomu g\u00f6stermez. Durum zamanla ilerledik\u00e7e, kad\u0131nlar adet ritminde bir k\u0131salma oldu\u011funu fark edebilir (\u00f6rne\u011fin 28 g\u00fcnl\u00fck d\u00f6ng\u00fc 24 g\u00fcne d\u00fc\u015fer). Menopoz yakla\u015ft\u0131\u011f\u0131nda, kad\u0131nlar s\u0131cak basmas\u0131, uyku g\u00fc\u00e7l\u00fc\u011f\u00fc, adet d\u00f6nemlerinin atlanmas\u0131 ve vajinal kuruluk gibi d\u00fc\u015f\u00fck \u00f6strojen belirtilerini fark edebilirler.<\/p>

    \u00a0<\/p>

    DOR Nas\u0131l Te\u015fhis Edilir?<\/strong><\/p>

    FSH ve Estradiol hormonlar\u0131n\u0131 \u00f6l\u00e7mek i\u00e7in adet d\u00f6ng\u00fcs\u00fcn\u00fcn ikinci veya \u00fc\u00e7\u00fcnc\u00fc g\u00fcn\u00fcnde al\u0131nan kan testleri de dahil olmak \u00fczere, yumurtal\u0131klar\u0131n fonksiyonel rezervini de\u011ferlendirmenin bir\u00e7ok yolu vard\u0131r. 12 mIU\/mL seviyesinin \u00fczerindeki FSH seviyelerinin hafif y\u00fckseldi\u011fi kabul edilir. 15 mIU\/mL’nin \u00fczerindeki seviyeler, yard\u0131ml\u0131 \u00fcreme giri\u015fimlerini iptal etmek i\u00e7in yeterince anormal kabul edilir, \u00e7\u00fcnk\u00fc bu aral\u0131ktaki hastalar do\u011furganl\u0131\u011f\u0131 art\u0131ran ila\u00e7lara tatmin edici bir \u015fekilde yan\u0131t vermeyecektir. Bu iki hormonun normal temel ekspresyonundaki dalgalanmalar, yumurtal\u0131k rezervinin azald\u0131\u011f\u0131n\u0131 g\u00f6sterir.<\/p>

    AMH (Anti-M\u00fcllerian Hormon), do\u011furganl\u0131k potansiyeli ile iyi ili\u015fkili olan ba\u015fka bir kan testidir. Bu hormon genellikle v\u00fccuttaki yumurta say\u0131s\u0131n\u0131 yans\u0131t\u0131r. FSH \/ estradiol kan testi ve g\u00f6r\u00fcnebilir antral folik\u00fcllerin say\u0131s\u0131n\u0131n (AFC) transvajinal ultrason de\u011ferlendirmesi ile birle\u015ftirildi\u011finde \u00f6zellikle yararl\u0131d\u0131r.<\/p>

    DOR te\u015fhisinde ba\u015fvurulacak \u00e7ok say\u0131da test olsa da, g\u00fcncel \u00e7al\u0131\u015fmalar, yumurtal\u0131k rezervini ve t\u00fcp bebek tedavisinde yumurtal\u0131k uyar\u0131m\u0131na v\u00fccudun verece\u011fi cevab\u0131 \u00f6ng\u00f6rmede en g\u00fcvenilir testlerin kanda bak\u0131lan AMH d\u00fczeyleri ve ultrason ile de\u011ferlendirilen antral folik\u00fcllerin say\u0131s\u0131 (AFC) oldu\u011funu g\u00f6stermi\u015ftir.<\/p>

    \u00a0<\/p>

    DOR Nas\u0131l Tedavi Edilir?<\/strong><\/p>

    Halihaz\u0131rda, yumurtal\u0131k ya\u015flanmas\u0131n\u0131 yava\u015flatan veya engelleyen hi\u00e7bir tedavi bulunmamaktad\u0131r. DOR belirlendikten sonra, uygulanan tedaviler gebe kalma s\u00fcresini h\u0131zland\u0131rmak veya bir hastan\u0131n gelecekteki kullan\u0131m\u0131 i\u00e7in yumurtalar\u0131 veya embriyolar\u0131 dondurmak amac\u0131n\u0131 g\u00fcdebilir. IVF uygulanan DOR hastalar\u0131, toplanan yumurta say\u0131s\u0131n\u0131 en \u00fcst d\u00fczeye \u00e7\u0131karmak i\u00e7in tipik olarak daha y\u00fcksek dozlarda yumurtal\u0131k stim\u00fclasyon rejimlerine al\u0131n\u0131r.<\/p>

    DOR’lu kad\u0131nlar i\u00e7in prognoz, te\u015fhis konulduktan sonra de\u011fi\u015fkenlik g\u00f6stermez. DOR, en erken a\u015famalarda bile gebelik ba\u015far\u0131s\u0131n\u0131 azalt\u0131r ve d\u00fc\u015f\u00fcklerde art\u0131\u015fa sebep olur. Hasta ne kadar ya\u015fl\u0131ysa, klinik tablo tipik olarak o kadar tehlikeye girer.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

    \u2018Yumurtal\u0131k Rezervi\u2019 terimi, oosit olarak da bilinen yumurtalar\u0131n\u0131z\u0131n say\u0131s\u0131 ve kalitesi anlam\u0131na gelir. Yumurtal\u0131k rezerviniz azalm\u0131\u015fsa bu durum, yumurtalar\u0131n\u0131z\u0131n say\u0131s\u0131n\u0131n ve kalitesinin ya\u015f\u0131n\u0131za g\u00f6re beklenenden daha d\u00fc\u015f\u00fck oldu\u011fu anlam\u0131na<\/p>\n","protected":false},"author":2,"featured_media":834,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[4,5,6],"class_list":["post-104","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-gebelik","tag-branding","tag-business","tag-photography"],"_links":{"self":[{"href":"https:\/\/drozkanozdamar.com\/index.php?rest_route=\/wp\/v2\/posts\/104","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/drozkanozdamar.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/drozkanozdamar.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/drozkanozdamar.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/drozkanozdamar.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=104"}],"version-history":[{"count":9,"href":"https:\/\/drozkanozdamar.com\/index.php?rest_route=\/wp\/v2\/posts\/104\/revisions"}],"predecessor-version":[{"id":1180,"href":"https:\/\/drozkanozdamar.com\/index.php?rest_route=\/wp\/v2\/posts\/104\/revisions\/1180"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/drozkanozdamar.com\/index.php?rest_route=\/wp\/v2\/media\/834"}],"wp:attachment":[{"href":"https:\/\/drozkanozdamar.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=104"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/drozkanozdamar.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=104"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/drozkanozdamar.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=104"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}